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Neto and coworkers analyzed the classical targets of CO (i.e., mRNA for IL-6, IL-1beta, TNF-alpha, ICAM-1, heme oxygenase-1, and inducible nitric oxide synthase) in a model of kidney transplantation in rats

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However, it is not an FDA-approved cessation tool and it is common for people to end up using both vapes and cigarettes concurrently, preventing cessation and increasing health risks