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In 1931, for the first time in more than a decade, total cigarette sales fell from 124 to 117 billion pieces

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Froelich, Incidence of tobacco & vaping in low-income, ethnically dense communities 42 11 32, 2020, D

COPD, the result of irreversible airway obstruction, is overwhelmingly caused by smoking. Early warning signs include persistent cough, frequent bronchitis, reduced exercise tolerance, unexplained weight loss, coughing up blood and new onset wheeze

Additional file1: Table S5 lists the method numbers and reporting limits for all of the analyses used