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A growing body of research suggests that the dysregulation of the nicotinic cholinergic system is responsible for modulating the sensory processing input processes, which accounts for the control issues that are typical of ADHD [73] nAChRs also have a role in the regulation of neurotransmitters including dopamine and serotonin

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There is uncertainty regarding the efficacy of treatments like baclofen (Lioresal) and naltrexone (Naltrexone)