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The aerosol can contain nicotine, cancer-causing chemicals, heavy metals (such as nickel and lead), and flavoring (such as diacetyl, a chemical that can cause a serious lung disease)

In the last decade, localization of neuronal nicotinic acetylcholine receptor (nAChR), a specific receptor of nicotine, has been widely detected in non-excitable cells [16]

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Lead, chromium, arsenic, and cadmium are among the more prominent hazardous metal components