If you leave the tobacco in your mouth for long periods of time, that is a lot of exposure to sugar
Muscle relaxation - Nicotine intervenes with the muscle relaxation of the esophagus, which leads to gastric efflux Esophageal lining - Nicotine damages the mucus membranes which protect the esophageal lining, which triggers the gastric efflux 2
By the 18th century the habit of snuff use had spread throughout much of the world, though in the 19th, and especially 20th, centuries nasal snuff had largely fallen into disuse
[2] Nasal snuff is a fine tobacco dust, flour, or powder meant for light insufflation, or "snuffing", popular and widespread mainly in the 18th century
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