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High-profit margins by the local retailers, the craze of the local youths for foreign cigarette brands at cheaper rates, the tempting flavour of some of the cigarette brands, etc

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Unpredictable composition with unknown chemicals and potency Eliminates pain, leading to severe unnoticed injuries High risk of permanent psychosis Stored in body fat, causing delayed re-intoxication Contains carcinogens (e.g., formaldehyde) linked to cancer No antidote

In line with the lower expression of miR-320d in control and COPD (ex-)smokers, we observed a significant negative correlation between miR-320d expression and packyears in the screening, but not validation cohort (Supplementary Fig