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"Our findings concur with others that stress and depression have a significant impact on fetal movements, and need to be controlled for, but additionally these results point to the fact that nicotine exposure per se has an effect on fetal development over and above the effects of stress and depression." "Technology means we can now see what was previously hidden, revealing how smoking affects the development of the fetus in ways we did not realize," co-author professor Brian Francis added

CHRNB3 Missense Variant and Smoking Reduction Effects The most significant finding was the p.Glu284Gly missense variant in the CHRNB3 gene, identified exclusively in participants of Indigenous Mexican ancestry (p = 1.1 10 -9 )

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[64] Mass.gov, 2019 Tobacco Control Law, [65] Mass.gov, DOR Cigarette and Tobacco Excise Tax, [66] Minn