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At the same time, accumulated research on EndMT showed that endothelial dysfunction contributes to the pathogenesis of pulmonary hypertension [132] and pulmonary vascular endothelial cell apoptosis can promote the development of pulmonary hypertension, which is a common complication of COPD and is closely related to COPD progression [133]

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During the Edo period, many samurai and chnin smoked tobacco, and often carried a kiseru in a special case called a kiseruzutsu