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This relationship is clearly observed in Japanese Americans due to the high prevalence of low or no-activity CYP2A6 alleles

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Let's face it, inhaling any chemical into the lungs is likely to be associated with some harm, but compared to the multiple known health risks associated with cigarette smoking which kills 81,700 people per year in England alone, the health risks of the non-combustible e-cigarette is likely to be in orders of magnitude lower