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Cardiovascular and Mortality Risk by Initiation Age Compared with nonsmokers, individuals who started smoking early and accumulated heavy exposure had more than double the risk of MI (HR 2.43), a markedly increased risk of stroke (HR 1.78), combined stroke or MI (HR 2.00), and elevated all-cause mortality (HR 1.82)

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smoking can bother or start: Thromboangiitis obliterans, in which blood clots happen in thin blood vessels thrombosis by thrombophilia, antiphospholipid syndrome, or medications including oral contraceptives