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Molecular studies have demonstrated that tobacco combustion products contain potent carcinogens, including polycyclic aromatic hydrocarbons (PAHs) and aromatic amines, which reach the bladder epithelium at high concentrations via urinary excretion, thereby inducing DNA damage 22

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We hypothesized that the smoking epidemic may have been the main contributor to the widening and subsequent narrowing of the male-female survival gap in high-income regions in the second half of the twentieth century

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