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Smokers respond poorly to the medicinal therapy

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People who tried them said they were worse than coffee grounds in a newspaper wrapper, and akin to smoking old socks. Several tobacco alternative researchers cited pungent, acrid, and objectionable burning odors and undesirable taste as major hurdles to their projects

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Cancer patients who continue smoking or using tobacco after diagnosis experience significantly worse outcomes, including increased tumor progression, higher rates of developing a second cancer, greater recurrence following treatment, and increased cancer-related mortality