This can vary by region and brand
Acid reflux refers to any episode of acid backflowing into the oesophagus
Le Foll B, Melihan-Cheinin P, Rostoker G, Lagrue G (2005) Smoking cessation guidelines: evidence-based recommendations of the French Health Products Safety Agency

Nicotine Effects: Central Nervous System Dizziness Lightheadedness Abnormal sleep disturbances Blood-flow risk Headache Nicotine Effects: Cardiovascular System Atherosclerosis Aortic enlargement and dissection Increased clotting Heart rate fluctuation Increased blood pressure Coronary artery disease Tachycardia Arrhythmias Nicotine Effects: Respiratory System Shortness of breath Chronic obstructive pulmonary disease Bronchospasm Cancer Nicotine Effects: Muscular System Spinal disc degeneration Joint pain Tremors Nicotine Effects: Gastrointestinal System Peptic ulcer Diarrhea Nausea Dry mouth Heartburn Dyspepsia Cancer Mentioned health effects can all be attributed to nicotine but are greatly exacerbated by other compounds usually found in tobacco products, such as tar, carbon monoxide, toluene, or any of the other 4,000 substances regularly found in cigarettes

In the CY 2018 Quality Payment Program final rule, commenters indicated that data aggregation across multiple TINs for Virtual Groups would be burdensome for rural and small practices and that this burden could be prohibitive for Virtual Groups' successful participation in MIPS (82 FR 53610)