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His instructions to the expedition stated: The object of your mission is to explore the Missouri River, & such principle stream of it, as, by its course and communication with the waters of the Pacific ocean, whether the Columbia, Oregon, Colorado or any other river may offer the most direct & practicable water communication across this continent for the purpose of commerce

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Travel: If the person has a recent travel history to a foreign country Bradycardia/Tachycardia: If the persons heart rate is less than 50 beats per minute or more than 100 BPM