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Collectively, these findings advance the mechanistic understanding of T-cellmediated immune regulation in IBD by elucidating how environmental exposures, particularly cigarette smoke, interact with host genetic factors such as GPR15 to drive heterogeneity in the disease phenotype and course
Despite the well-documented risks of tobacco use, maternal smoking during pregnancy remains prevalent
Similarly, self-care as assessed by Self-care Inventory-Revised and the Problem Areas in Diabetes Scale was worse for current tobacco users compared with never users, as were reported diabetes distress and frequency of SMBG ( P .001 for all)
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