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The overarching goal of the Penn State TCORS was to understand the health impact of tobacco-harm reduction policies in vulnerable (e.g

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29 Snuff use leads to higher accumulated nicotine levels and a more continuous exposure on the nicotine receptors, compared with short, intermittent exposure in smoking, which may explain differences between effects of smoking and snuff use

Surface secretory cells shift their mucin programs toward a MUC5AC -dominated inflammatory state while SMG secretory cells lose many of their distinctive defensive secretions