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Nicotine may also contribute to the hardening of the arterial walls, which in turn, may lead to a heart attack

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While these products are not safe, many believe they are significantly safer than combustible cigarettes

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(Interestingly, history is repeating itself now with the increasing popularity of e-cigarettes, which produce several vaporized chemicals, have no regulatory oversight, and contain varying amounts of nicotine.) Cigarette smoke is a complex mixture of gases and submicron-size particulate matter [35]