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Similar heterogeneity was observed in sample sizes, so we evaluated the impact that small sample sizes may be having on model results by restricting the input data to only observations with more than five participants each in the exposed and unexposed case and control groups

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Post-hoc, because of the low number of participants in the relapse group and thus analysis of results in only the cessation group, the power of the study was calculated as 91.4% using the R package pwr, the function pwr.t.test, an alpha of 0.05, based on the mean and standard deviations of the difference in systolic home BP delta value between the run-in and week 12

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