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Therefore, the changes in the size and composition of longitudinal bundles in smoking asthmatics may further aggravate airway remodeling by affecting the mechanical properties of the airway or the folding behavior of the airway mucosa 45,83

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NNN in particular is highly relevant to the health effects of cigars because it is a powerful oral cavity and esophageal carcinogen in rats when given in drinking water, while a mixture of NNN and NNK also produced oral and lung cancers in rats when applied in the oral cavity (Balbo et al., 2013