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Although these pathways show that exposure to nicotine directly disrupts monoaminergic systems, disruptions of the endogenous cholinergic system, whether direct or indirect, remain a possibility

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This increased interest led to 100 scientific articles being published in the latter half of the nineteenth century on the therapeutic effects of cannabis [21], including a report on the isolation of the first cannabinoid (cannabinol [CBN]) in 1899 [22]

This includes dogs, cats, birds, small pets such as rabbits and guinea pigs and even fish