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Additionally, smoking was associated with a significantly increased risk of IBS-diarrhea, while this only applied to the highest exposure category (20 or more cigarettes per day), there was a trend for a dose-response relationship

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they also discussed the 1 quarternary amine methyl nicotine in which an additional methyl group resides on the pyrrolidine N

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Charging takes about 30-60 minutes, with completion indicated by a dimmed or color-changed LED