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Del Toro gained more than 45 pounds (18 kg) in nine weeks before filming began, eating 16 donuts a day, [13] and extensively researched Acosta's life

Ash Tray And Cigarette Packet is a photograph by Sheila Terry / Science Photo Library which was uploaded on September 21st, 2018

Severity scores of physical (out of 11) and psychological (out of 8) withdrawal symptoms for each participant were assessed and calculated for each participant, depending on the symptoms reported

The inclusion/exclusion criteria for the selection of studies were based on the PICO framework

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