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10.1111/j.1600-051X.2005.00847.x 44

60 ASM cells cultured from a restricted group of COPD patients showed a collapsed mitochondrial membrane potential, an increased expression of mitochondrial fission protein and reduced respiratory complex protein, and accumulation of mitochondrial ROS, which contribute to the development of airway hyperresponsiveness and lung inflammation

Of course, the proportions of tobacco are different depending on the side

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Each herb, smoke, bud, or smoking blend has its own unique properties and effects.