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During smoking, this complex biomass is subjected to high temperatures and varying oxygen concentrations, producing an incomplete combustion that generates more than 7,000 toxic compounds

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Supplementary Table S4) 27,28,29,30,31,32,33,34,35

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Cortijo et al., The Relaxant and Spasmogenic Effects of Some Xanthine Derivatives Acting on Guinea-pig Isolated Trachealis Muscle, British Journal of Pharmacology, August 1988;94(4):10911100