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Crystals of ciprofloxacin have been observed rarely in the urine of human subjects but more frequently in the urine of laboratory animals, which is usually alkaline [see Nonclinical Toxicology (13.2)]

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This suggests theres a double whammy effect to combining smoking and drinking

In hypertensive mice with deficient lysosomal cathepsin S in macrophages, mitophagy was inhibited, resulting in elevated ROS levels and NF-B activity, exacerbating cardiac inflammation and fibrosis (Pan et al., 2012)