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8.1 Pharmacological interventions targeting mitochondria Mitochondrial dysfunction plays a significant role in various inflammatory lung diseases, including asthma, COPD, and pulmonary fibrosis

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In contrast, under acute explosive stress conditions, such as sepsis or severe smoke damage, dysregulated mitophagy or a mismatch between mitochondrial clearance and renewal may contribute to epithelial vulnerability and cell loss, particularly when bioenergetic reserve is limited

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