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The main measure was the excess relative risk for smoking one cigarette per day (RR1_per_day1) expressed as a proportion of that for smoking 20 cigarettes per day (RR20_per_day1), expected to be about 5% assuming a linear relation between risk and consumption (as seen with lung cancer)

Focusing on the last possibility, nAChRs are ubiquitous throughout the human brain with particularly high densities in the thalamus, insula, and vmPFC [68, 69]

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