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Since IL-1 engages an IL-1 receptor on ILC3s and promotes their proliferation and IL-17A production 14 , these findings suggest that the smoking-induced sputum ILC3s and circulating memory-like CD4 + CD45RO + ILC3 subset in asthma patients could be generated by smoke-damaged airway epithelial cells rather than circulating immune cells

He made a poignant return as Iceman in Top Gun: Maverick (2022), a nod to his lasting legacy in Hollywood