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"Therefore, even though some individuals are exposed to high levels of biological stressors, like those found in cigarette smoke, their bodies may be better set up to cope with and repair the damage." The researchers conclude that long-lived smokers may represent a "biologically distinct group, endowed with genetic variants allowing them to respond differentially to environmental stressors"

In that article, he talks about the dramatic rise in lung cancer since 1900, and the potential reasons that have been advanced for it, but stops short of drawing the direct connection to cigarettes

An earlier study concluded that lower ignition propensity cigarettes could be made while still retaining acceptable smoke yields and activity in an in vitro Ames test (Harris 1992)

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10.1177/1934578x1000500328 2 AdeosunT