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The effectiveness of an adsorbent such as HAC is likely to be weaker in smaller circumference cigarettes because, at a fixed puff volume, the flow rate of air through the cigarette is increased at smaller circumferences owing to the reduced volume

The earliest connection between p53 and NER was demonstrated by Smith et al., where they found that human cells in which normal p53 function was disrupted by either the human papillomavirus E6 oncoprotein or expression of a transgene encoding a dominant-negative mutant of p53 showed significantly reduced tolerance to UV irradiation [43]