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A reduction in cortisol levels complements this effect, the primary stress hormone that typically surges during nicotine withdrawal, exacerbating cravings, anxiety, and emotional dysregulation

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48 Concurrently, cigarette manufacturers were seeking to reassure their customers that their products were safe, that if hazardous compounds were identified they would be removed, and that product modifications could help to reduce risks

The idea had been swirling around the department for more than a year, according to Mitchell