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How much does your father smoke? Like a chimney. How long has he been smoking? Forty years. Does he cough? All the time. Worried about his heart? Yes, as a matter of fact, his hearts thumping. Breathing? He pants like an old locomotive. Wives and daughters turned into diagnosticians

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Systems toxicology investigations indicated that nicotine exposure also affected metabolic pathways the in liver, including upregulation of fatty acid beta-oxidation, cholesterol synthesis, gluconeogenesis, and ketone body formation pathways

Tobacco use also promotes pain sensitivity while simultaneously blunting the efficacy of many pain medications