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Overall, nAChR dysfunction may influence the aberrant signaling of glutamate, GABA, and dopamine of which nicotine use may partially alleviate ( Circuitry Dysfunction It is posed that each transmitter system, including dopamine, glutamate, GABA and cholinergic neuronal transmission, incorporates a circuit, supported by genetic risk, that facilitates a risk for SZ presentation (61, 111)

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