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At clinical concentrations, pretomanid does not inhibit major CYP isoenzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19 or CYP2D6, and does not induce CYP2C9 or CYP3A4, limiting the potential for DDI trough CYPs

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Rates remain high among low-income Americans (24.4 percent), rural residents (27 percent), people with disabilities (21.5 percent), and workers in construction and extraction jobs (around 29 percent)

However, if your symptoms don't improve within a few days, or you are concerned about them, call a healthcare provider