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Autosomal dominant mutations in the COL1A1 or COL1A2 genes in OI patients disrupt the synthesis and structure of type I collagen, which in turn leads to Osteogenesis Imperfecta, also known as the brittle bone disease

[14] While Calverleys wry humour mocks those in the medical community with outlandish comparisons to animal sentience, the joke relies on a contemporary belief (still held by us moderns) that animals are less than humans and thus solely used for testing and consumption

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Interestingly, the threshold for sensory nerve stimulation and cough is reduced in the presence of inflammatory mediators, and inhalation of these mediators and low pH can induce coughing in both humans and animals

The latest can, Manzanita, is the story of a crisp, fall night, showcasing close-ups of manzanita leaves and camping tents along the Northern California coast where manzanita is a native plant, she said