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We hypothesize that the gradual reduction of nicotine from progressively lowering nicotine exposure will lead to lower levels of blood nicotine metabolites and nicotine-derived carcinogens, while not affecting overall cigarettes smoked per day Determine the modifying effect of menthol on progressive nicotine content reduction and biomarkers

This mechanism that controls our gene expression is a tightly regulated mechanism that happens in our body in a non-random manner

We show this in Figure 1

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