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Cigarette smoke induces COPD-related airway remodeling phenotypes, including airway epithelial hyperplasia, myocyte hyperplasia, squamous metaplasia, EMT, ciliary alterations, loss of secretory cells that produce Scgb1a1, and reduced integrity of the apical junction barrier that controls airway epithelial permeability

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The price of a 20-pack is higher than the equivalent of 20 in New Zealand, and 25 in Australia

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Similarly, individuals under 21 attempting to purchase or possess these products can face penalties, typically fines (up to $100) or community service