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It took the FDA, for example, four years to issue the first approval of a flavored vaping product four versions of NJOY Menthol.[64] Beyond the opportunity cost of waiting to bring products to market, the typical costs for securing FDA approval are enormous

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Lower therapeutic doses (25-100mg) rarely cause problems

The reconstruction costs have threatened to weigh on Japans public finances at a time when public debt is twice the size of its economy

So the strategy of selling cigarettes in cartons also increases their sales because you are providing more cigarettes to a customer at a time