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Tighter skin barrier lipid packing has also been shown to be due to lower SC hydration 39 which has been found in the skin of smokers in several studies mainly in areas with low sebum levels including the volar forearm 4, 7, 8, 23

As a result of the different diagnostic criteria employed in different studies, significant heterogeneity exists amongst available literature, and the percentage prevalence of IBS varies immensely internationally (3)

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