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Focal retinal laser photocoagulation has historically been the gold-standard treatment if edema is present for 3 to 6 months duration, and visual acuity is below 20/40 with macular capillary perfusion

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Additional confirmatory evidence for 6MN in Table 1 samples was obtained by LC/MS/MS with high resolution MS1/MS2 using high resolution MS1 scanning for M+H + at the 6MN LC retention time (see Table 7 below) at 177.1386 amu (= 12 C 11 1 H 17 14 N 2 + = 12 C 11 1 H 17 14 N 2 minus m electron ) then examination of the MS2 spectrum against the authentic standard