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Before starting, inform your doctor if you have heart disease, high blood pressure, stomach ulcers, diabetes or any dental work

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A recent network meta-analysis assessing oral health effects across non-combustible nicotine products did not identify any eligible randomized controlled trials on nicotine pouches, and the relatively short follow up period of the included studies did not allow for evaluation of their potential impact on oral carcinogenesis (60, 61)

Published in 1986, it is the first major study [1] that synthesized the historiography of the colonial Chesapeake region of the United States