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Spain tobacco firms to pay to clean up cigarette butts Tobacco companies will now be charged to clean up cigarette butts off the streets and beaches of Spain, according to new environmental regulations

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33 Wang et al demonstrated that epigenetic silencing of miR-218 is involved in the acquisition of CSC-like properties and malignant transformation of human bronchial epithelial cells induced by long-term tobacco smoke exposure

Table 4 shows a negative but nonsignificant total indirect effect (-0.007), alongside negative (and nonsignificant) single-mediator indirect effects through M1 (-0.005) and M2 (-0.003), yet a positive and significant serial component (0.001)