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Most importantly, they strongly suggest that tobacco control measures, particularly when implemented comprehensively, work, collectively leading to a 27.2% (95% CI: 26.0% to 28.3%) global decline in smoking prevalence among men since 1990, and a much larger decline, 37.9% (95% CI: 35.3% to 40.1%) among women.31 32 The substantial declines observed among the higher sociodemographic group demonstrate their effectiveness among populations having greater access to health resources and choices that enhance health consciousness, responsiveness to health messages and avoidance of health risks than other sectors of the population

J Subst Abuse

[1] The IARC monographs conclude that mice with prolonged exposure to simulated second-hand smoke, that is six hours a day, five days a week, for five months with a subsequent four-month interval before dissection, will have significantly higher inicidence and multiplicity of lung tumors than with control groups

Figure 9

If you notice a burnt taste or a significant drop in flavour, it is time to replace it