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In other countries, especially those in Southeast Asia, where chewing betel nuts is more common, oral cancers appear more frequently on the gums and inner cheek

John Wesley's Primitive Physick , first published in 1747, recommended it for earache (blow the smoke of tobacco strongly into it), for falling sickness, and for piles (apply a tobacco leaf steeped in water twenty-four hours)

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By the 1960s, with more reports by the Surgeon General, and more bad press, there started to be an upsurge in grass-roots guerilla tactics against smoking namely second-hand smoke