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While it is uncertain whether or not cannabis is mentioned in the Hebrew Bible, it is safe to say that, from a biblical perspective, God did not deem any plant evil, nor did God prohibit the consumption of any plant with one notable exception of a particular tree in the Garden of Eden

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Theres a lot we are just learning about them, Mar says

[85] Minimal exposure could be enough to produce neuroplastic alterations in the very sensitive adolescent brain

This dosage is often the most suitable for regular smokers (+15 cigarettes/day) or those with strong dependence