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Microbial communities in different sections of the gut, such as the small intestine and colon, vary in species composition and functional capacity, meaning that fecal samples may not fully reflect the diversity and dynamics of the intestinal microbiome [130,131,132]

Roh et al

However, if you have additional health issues, you are looking at much higher rates than the rates I illustrated

In addition, individuals who smoke conventional cigarettes and use e-cigarettes (dual use) showed the highest likelihood of developing COPD compared with those who have never smoked conventional cigarettes or used e-cigarettes [108, 110,111,112]