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Molecularly, EMT is characterized by downregulation of epithelial junction proteins (e.g., E-Cadherin and Occludins) and activation of EMT transcriptional activators (e.g., Snail, Slug, and Twist) and mesenchymal markers (e.g., S100A4, Vimentin, Fibronectin, and N-Cadherin) [63]

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For example, heavy smokersthose with higher pack-years (a measure combining the number of packs smoked per day and years smoked)face significantly greater risk compared to light or moderate smokers

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