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In the past, tobacco companies have used flavorings such as essential oils to enhance tobacco products [13]

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Study outcomes The primary outcome was the comparative bioavailability of nicotine from the Test and Reference products, as assessed by the maximum observed concentration of nicotine (C max ) occurring at time T max , and the area under the plasma concentrationtime curve calculated from 0 min to the time of the last measurement (AUC 0-T )

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