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The condition is caused by long-term exposure to irritants such as smoke, leading to irreversible lung damage

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Oxidative stress: This is when there are too many unstable molecules called free radicals in the body and not enough antioxidants to get rid of them

Svartberg J, Jorde R (2007) Endogenous testosterone levels and smoking in men

Rehydration was performed with two 3 min washes in HistoChoice, followed by a standard ethanol dilution series, and antigen retrieval in Antigen Unmasking Solution for three 4-min boiling intervals