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The molecules present in tobacco and tobacco smoke begin to act in the body only after enzymatic activation that can be achieved by cytochrome P450 2A13 (P450 or CYP) and is considered a key reaction pathway for initiation of bioactivation of carcinogenesis, and consequently of the progressive changes in the biological profile of the cell [13,14]

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The situation, with children as young as 12 (and HRW found about a dozen kids conducting lighter work in the fields who were under 12), is so absurd that it proved to be great material for the satirists at The Daily Show with Jon Stewart, who produced an entertaining, but alarming, report called Nicoteens. The clip is comical and allows you to hear young tobacco workers describing the work conditions in their own words, but child labor in U.S

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